The ISS Acoustics Office provides space flight mission support on all acoustic-related issues and tasks. As part of this support, we define, develop, and implement requirements for a comprehensive noise mitigation program for space flight and the International Space Station. To ensure these requirements are complied with, we utilize on-orbit testing to define the environment, derive measures to safeguard the health, safety, and well being of flight crewmembers, and work on measures to reduce unacceptable levels. This program preserves crewmembers' hearing and provides for a safe, productive, and comfortable noise environment. This paper describes crew training with acoustic measurement devices, on-orbit testing, real-time remedial actions, the types of data produced, and examples of recommendations that are made to protect the crewmember's hearing.