[Immune system in Russian cosmonauts after orbital space flights]
Rykova, M. P. (2013). "[Immune system in Russian cosmonauts after orbital space flights]." Fiziol Cheloveka 39 5: 126-36
The article is an overview of the results of studies of the immune systems of cosmonauts. The use of a system approach to the evaluation of the various components of the immune system made it possible to identify a number of characteristics of adaptive change, including the quantitative and functional changes of the innate and adaptive immunity. Among them the most important are: changes in in the system of Toll like receptors (TLRs) manifested as a decrease in the content of circulating monocytes and granulocytes expressing TLR2, TLR4, and TLR6, and LPS-induced cytokine production; inhibition of the functional potential of natural killer (NK)- and T-cells. The article discusses possible factors and mechanisms of the identified changes.
ISSN: 0131-1646 (Print) 0131-1646 (Linking)
Accession Number: 25509881