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PROTEIN CRYSTALLIZATION FOR DRUG DEVELOPMENT: A Prospective Empirical Appraisal of Economic Effects of ISS Microgravity

Nicholas S. Vonortas (2015). "PROTEIN CRYSTALLIZATION FOR DRUG DEVELOPMENT: A Prospective Empirical Appraisal of Economic Effects of ISS Microgravity." NASA Final Report

The paper proceeds as follows. Section two below discusses the topic of protein crystallization in biomedical research as well as our current understanding regarding the contribution of microgravity in developing better quality crystals. Section three addresses possible policy intervention, also including the introduction of a government funded consortium to diffuse risk. Section four outlines a specific model that has recently been developed by RTI International, which provides an interesting quantitative framework for measuring private sector costs. The outcome of this section is essentially a list of needed data and data sources. Finally, Section five concludes.

Related URLs:
http://www.ige.unicamp.br/spec/wp-content/uploads/sites/15/2015/07/Report-NASA_Modeling-Drug-Development-and-Protein-Crystals_2015.pdf

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Tags: Biopharmaceutical, CASIS, commercialization, FDA, International Space Station, ISS, LEO, logistics, Low Earth orbit, membrane protein, Microgravity, NASA, pharmaceutical, private sector investment, Protein Binding, Protein crystalization, structure-based drug design, synchrotron, X-ray crystallography, X-ray diffraction