Self-assembled Gels of Amphiphilic Sequential Peptide in Water and Organic Solvents
Cai, Rong, et al. (2011). "Self-assembled Gels of Amphiphilic Sequential Peptide in Water and Organic Solvents." Chemistry Letters 40 6: 617-619
An amphiphilic peptide designed with serine as a polar residue showed gelation in both water and organic solvents. This sequential peptide has a strong tendency to adopt β-sheet conformation in these solvents. Such gels of β-sheet peptide based on hierarchical self-assembly consist of nanofiber construction because of the β-sheet structure, and because of crosslinking attributable to hydrogen bonding among hydroxy groups of the serine side chain.