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The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station

Smith, S. M., et al. (2005). "The nutritional status of astronauts is altered after long-term space flight aboard the International Space Station." J Nutr 135 3: 437-43

Defining optimal nutrient requirements is critical for ensuring crew health during long-duration space exploration missions. Data pertaining to such nutrient requirements are extremely limited. The primary goal of this study was to better understand nutritional changes that occur during long-duration space flight. We examined body composition, bone metabolism, hematology, general blood chemistry, and blood levels of selected vitamins and minerals in 11 astronauts before and after long-duration (128-195 d) space flight aboard the International Space Station. Dietary intake and limited biochemical measures were assessed during flight. Crew members consumed a mean of 80% of their recommended energy intake, and on landing day their body weight was less (P = 0.051) than before flight. Hematocrit, serum iron, ferritin saturation, and transferrin were decreased and serum ferritin was increased after flight (P < 0.05). The finding that other acute-phase proteins were unchanged after flight suggests that the changes in iron metabolism are not likely to be solely a result of an inflammatory response. Urinary 8-hydroxy-2'-deoxyguanosine concentration was greater and RBC superoxide dismutase was less after flight (P < 0.05), indicating increased oxidative damage. Despite vitamin D supplement use during flight, serum 25-hydroxycholecalciferol was decreased after flight (P < 0.01). Bone resorption was increased after flight, as indicated by several markers. Bone formation, assessed by several markers, did not consistently rise 1 d after landing. These data provide evidence that bone loss, compromised vitamin D status, and oxidative damage are among critical nutritional concerns for long-duration space travelers.

Related URLs:
http://www.ncbi.nlm.nih.gov/pubmed/15735075

ISSN: 0022-3166 (Print) 0022-3166 (Linking)

Accession Number: 15735075

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Tags: Adult, Astronauts, Biological Markers, Body Composition, Deoxyguanosine, Dietary Supplements, enzymology, Female, Humans, International Cooperation, Male, Middle Aged, Nutritional Status, oxidative stress, Space Flight