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The SCD – Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission

Versari, Silvia, et al. (2015). "The SCD – Stem Cell Differentiation ESA Project: Preparatory Work for the Spaceflight Mission." Microgravity Science and Technology 28 1: 19-28

Due to spaceflight, astronauts experience serious, weightlessness-induced bone loss because of an unbalanced process of bone remodeling that involves bone marrow mes- enchymal stem cells (BMSCs), as well as osteoblasts, osteo- cytes, and osteoclasts. The effects of microgravity on osteo- cells have been extensively studied, but it is only recently that consideration has been given to the role of BMSCs. Pre- vious researches indicated that human BMSCs cultured in simulated microgravity (sim-μg) alter their proliferation and differentiation. The spaceflight opportunities for biomedical experiments are rare and suffer from a number of opera- tive constraints that could bias the validity of the experiment itself, but remain a unique opportunity to confirm and explain the effects due to microgravity, that are only par- tially activated/detectable in simulated conditions. For this reason, we carefully prepared the SCD – STEM CELLS DIFFERENTIATION experiment, selected by the European Space Agency (ESA) and now on the International Space Station (ISS). Here we present the preparatory studies per- formed on ground to adapt the project to the spaceflight constraints in terms of culture conditions, fixation and stor- age of human BMSCs in space aiming at satisfying the biological requirements mandatory to retrieve suitable sam- ples for post-flight analyses. We expect to understand better the molecular mechanisms governing human BMSC growth and differentiation hoping to outline new countermeasures against astronaut bone loss.

Related URLs:
http://link.springer.com/article/10.1007/s12217-015-9466-5

ISSN: 0938-0108 1875-0494

DOI: 10.1007/s12217-015-9466-5

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Tags: *Osteoblasts, Aging/physiology, Bone, Bone loss, bone marrow mesenchymal stem cells, bone mineral content, Bone Remodeling, Differentiation, epigenetics, Gene Expression, International Space Station, ISS, mesenchymal stem cell, Microgravity, Osteoclasts/metabolism/*pathology, Osteoporosis, Random positioning machine, stem cells, Transcriptomics