INTRODUCTION: In this study we investigated the effects of microgravity on the fiber properties of the mouse triceps brachii, a forelimb muscle that has no antigravity function. METHODS: Mice (n = 7) were exposed to microgravity for 13 days on the space shuttle Atlantis (Space Transportation System-135). The fiber cross-sectional area (CSA) and succinate dehydrogenase (SDH) staining intensity of the triceps brachii muscle were compared with those of controls (n = 7). SDH activity in this muscle was also estimated. RESULTS: Microgravity did not affect the body weight, muscle weight, or fiber CSA, but there was reduced SDH staining intensity of all types of fibers, irrespective of the muscle region (P < 0.05). Microgravity also reduced muscle SDH activity (P < 0.05). CONCLUSIONS: Short-term exposure to microgravity induced a decrease in oxidative capacity, but not atrophy, in the triceps brachii muscle of mice.
Related URLs:
http://www.ncbi.nlm.nih.gov/pubmed/25307981
